Supplemental Data
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posted on 2024-10-23, 12:05 authored by Vinicius Martins de Oliveira, Caique C. Malospirito, Fernando Bruno da Silva, Natalia B. Videira, Marieli M. G. Dias, Murilo N. Sanches, Vitor Leite, Ana Migliorini FigueiraThe SI contains the details on the Dual-Basin Structure-Based Model (db-SBM), randomly chosen structures from the transition state ensemble of PPAR$\gamma$ WT and I290M (Figure S1), and PPAR$\gamma$ mutants' biophysical analysis: PPAR$\gamma$ Far-UV CD absorbance profile curves and secondary structure content values (Figure S2). Derivation of Fluorescence Decay Rate (330nm/350nm) from Thermal Denaturation Curve of PPAR$\gamma$ WT + Rosiglitazone (Figure S3).
