Supplement Number 1

Force field parameters of choline cation, chloride and glycerol; Average, hydrophobic and hydrophilic SASA (nm2) versus wt% water plot of total lysozyme; percentage plots of α-helix, β-sheet, coil, bend, turn and β-bridge present in lysozyme, normalized 〈n_HB 〉 protein-water and glycerol-water, snapshot corresponding two peak values in choline-chloride RDF at different glyceline concentration; Snapshot of each simulated system at different glyceline concentration.