Fig. S4

Histological evaluation of NeuroRoots along the insertion trajectory. Histological verification of a 90-days-post-implantated, large PEDOT:PSS coated NeuroRoots implanted with a 100 µm diameter microwire. High magnification images show horizontal cross sections of the tissue response around the (i) tip of the implant and in the hippocampus (ii) along the trajectory of the implant in the cortical region above the hippocampus. GFAP staining (green) show reactive astrocytes 90 days post-implantation whereas DAPI (blue) labels cell nuclei in the neural tissue. Thin white arrows show tissue reaction (GFAP), whereas bold white arrow shows the pyramidal layer of the hippocampus. Scale bar: 100 µm